In the study by Elsinga et al. (, cellular accumulation of [11C]verapamil was 3.5-fold higher (345 ± 102 pmol/106 cells) in the human ovarian carcinoma cell line A2780 than in the corresponding Adriamycin-resistant cell line 2780AD (77 ± 15 pmol/106 cells). 2780AD cells were found to have higher P-gp expression than the A2780 cells. In a study comparing a P-gp-negative small cell lung carcinoma (GLC4) and its overexpressing subclone (GLC4/P-gp), cellular accumulation of [11C]verapamil in GLC4 was 1.3-fold higher than in GLC4/P-gp (10). Phenol,4-[(1E)-2-(3,5-dimethoxyphenyl)ethenyl]-Cyclosporin A increased [11C]verapamil accumulation by 1.0-fold in GLC4/P-gp but had no effect in GLC4.
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