What is Erlotinib HCl ?

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What is Erlotinib HCl ?

Post  disney on Mon Apr 26, 2010 12:35 pm

Erlotinib hydrochloride has the molecular formula C22H23N3O4•HCl and a molecular weight of 429.90. The molecule has a pKa of 5.42 at 25°C. Erlotinib hydrochloride is very slightly soluble in water, slightly soluble in methanol and practically insoluble in acetonitrile, acetone, ethyl acetate and hexane.
Erlotinib-HCl is a drug used to treat non-small cell lung cancer, pancreatic cancer and several other types of cancer. it is a cancer chemotherapy medication. Erlotinib interferes with the growth of cancer cells and slows their growth and spread in the body.It is used in the treatment of non-small cell lung cancer. Erlotinib may also be used for purposes other than those listed in this medication guide.

Erlotinib has recently been shown to be a potent inhibitor of JAK2V617F activity. JAK2V617F is a mutant of tyrosine kinase JAK2, is found in most patients with polycythemia vera (PV) and a substantial proportion of patients with idiopathic myelofibrosis or essential thrombocythemia. The study suggests that erlotinib may be used for treatment of JAK2V617F-positive PV and other myeloproliferative disorders.

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